Type 2 diabetes, fatty liver, high blood pressure, most cardiovascular disease, a good deal of hormonal disruption and a growing share of cognitive decline share one upstream mechanism: insulin resistance and the chronic inflammation that travels with it. They are usually treated as separate diseases with separate drugs. They often are not separate.

That reframing changes what counts as treatment. If the driver is constant insulin signalling from refined carbohydrate, industrial seed oils and eating from waking to sleeping, then the interventions that matter are the ones that interrupt it — removing the foods that provoke it, giving the body real time without food, and rebuilding the mitochondrial capacity that decades of the modern diet wore down.

None of this is fringe biochemistry. Most of it is uncontroversial in the literature and simply slow to reach the clinic, where guidelines move by consensus and the incentives do not favour interventions nobody can patent. We publish what the research supports, we say plainly when something is preliminary, and we expect you to check it yourself.