What Actually Extends Healthspan
The longevity field is full of compounds that work in worms. What holds up in humans is a shorter and much less exciting list.
longevity
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NAD+, NMN and NR: Promising Biology, Thin Human Evidence
NAD+ genuinely declines with age and genuinely matters. Whether swallowing a precursor changes anything you would notice is a separate and much less settled question.
Terrain Theory, Insulin Resistance, and the Root Cause of Chronic Disease
Modern chronic diseases are not random occurrences; they stem from an altered internal terrain driven by insulin resistance, diet, and lifestyle choices.