High-Dose Vitamin D Does Not Prevent Fractures in Bone-Sufficient Older Adults
Long-term trials show high-dose vitamin D3 does not reduce fracture risk in older adults who already maintain sufficient baseline serum levels.
Vitamin D
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When Vitamin D Supplementation Poses Risks: Understanding Hypercalcemia and Key Contraindications
While vitamin D is critical for metabolic health, its ability to dramatically increase calcium absorption creates risks under specific medical conditions and drug therapies.
Vitamin D and Immune Regulation: How Calcitriol Controls Inflammation and Pathogen Defense
Vitamin D functions as an immunomodulatory hormone, regulating regulatory T cells, supporting cathelicidins, and modulating inflammatory cascades across seasonal infection cycles.
Safely Navigating High-Dose Vitamin D: Co-Factors, Calcium Kinetics, and Toxicity Thresholds
Vitamin D toxicity stems from hypercalcemia rather than the vitamin itself. Proper co-factors like K2, magnesium, and hydration make targeted protocols safe.
The Evolutionary Origin of Vitamin D: From Solar Protection to Calcium Homeostasis
Tracing vitamin D from its ancient origins as a marine sunscreen to its vital modern role in intestinal calcium absorption and skeletal integrity.
Vitamin D and the Gut Microbiome: How Solar Hormone Status Shapes Microbial Diversity and Gut Barrier Integrity
Vitamin D directly shapes gut microbial diversity, supports butyrate production, and reinforces the intestinal epithelial barrier against systemic inflammation.
Vitamin D in Non-Obese PCOS: Disentangling Adiposity from Endocrine Dysfunction
Serum vitamin D levels in normal-weight women with polycystic ovary syndrome match healthy controls, showing that deficiency is driven by body composition rather than the condition itself.
Vitamin D Repletion in Autoimmune Hypothyroidism: Reducing Anti-TPO Autoantibodies and TSH
High-dose vitamin D supplementation significantly reduces elevated TSH and lowers anti-TPO autoantibodies by over 50 percent in women with autoimmune hypothyroidism.
Vitamin D and Allergic Disease: What Comprehensive Review Data Reveals About Hives, Eczema, and Rhinitis
An umbrella review of data from over 66,000 individuals shows vitamin D repletion reduces symptoms in hives, eczema, and allergic rhinitis, but fails to alter asthma or food allergies.
Vitamin D Repletion in Youth Depression and Anxiety: Evaluating Dosage, Baseline Severity, and Clinical Outcomes
High-dose vitamin D3 supplementation in deficient young people shows targeted reductions in anxiety and severe depressive symptoms, though outcomes depend heavily on baseline severity.
Vitamin D Repletion in Parkinson's Disease: Correcting Serum Levels Without Short-Term Clinical Reversal
Daily vitamin D3 supplementation normalizes blood levels in Parkinson's patients, but short-term trials show no immediate improvement in motor function or cognitive scores.
Vitamin D and Cardiometabolic Risk: Why Baseline Status and Age Dictate Results
Evaluating how vitamin D supplementation influences blood pressure, LDL cholesterol, and glycemic control across different age groups and baseline blood levels.
Vitamin D and Diabetic Kidney Disease: What the Evidence Shows About Protein Leakage and Organ Survival
Vitamin D lowers urinary protein leakage in diabetic kidney disease, but evidence shows no clear preservation of long-term filtration capacity or overall organ survival.
Autoimmunity: Starting at the Barrier
Different autoimmune conditions attack different tissue, but they share a mechanism — and one of the few modifiable inputs sits in the gut wall.
Vitamin K2 Decides Where the Calcium Goes
Largely absent from modern diets because it comes from fermented food and pastured animal fat — and it is the difference between calcium in bone and calcium in artery wall.
Vitamin D: The Dose Nobody Can Give You
Less a vitamin than a hormone, and one of the few supplements where deficiency is genuinely widespread at northern latitudes. The right dose varies more between people than for anything else on the shelf.